Empire AI Projects at UB Showcase Our Commitment to Realizing AI for Good

University at Buffalo Consortium member

Launched in April 2024 by Governor Kathy Hochul, Empire AI is a bold partnership of New York’s leading public and private universities coming together to establish a state-of-the-art artificial intelligence computing center, housed at SUNY’s University at Buffalo. Empire AI is already facilitating statewide innovation, research, and development of AI technologies.

Explore Empire AI Projects at UB

Physician reviewing AI enhanced medical imaging.

AI-Assisted Computational Pathology

AI-enhanced medical imaging

A multidisciplinary team will employ Empire AI’s computing power to create an AI tool that helps doctors better diagnose and monitor diseases. It will generate biomedical images by combining pathology reports with image-generating AI models that are trained on medical scans. The tool could lead to more sophisticated models that integrate genetic data with medical imaging.

Young girl using AI to perform interactive speech-language therapy.

AI-Powered Speech Therapy

An Interactive Multimodal Language Model for Children

UB researchers will utilize Empire AI to build an agentic, multimodal large language model to perform real-time, interactive speech-language therapies for children with speech and language challenges. This model will be used by the National AI Institute for Exceptional Education and is designed to plan, deliver, and adapt interventions in real-time based on the child’s responses and scene dynamics.

Man holding smartphone communicating with digital chatbot.

Personalized LLMs

Enhancing Human-AI Interaction

A UB research team within the Department of Communicative Disorders and Sciences focuses on an area of AI research known as personalization of large language models. This involves training models to learn the preferences and behaviors of users to fine-tune their experiences using chat bots. The project will leverage Empire AI to develop tools to ensure that people with ALS (also known as Lou Gehrig’s disease), cerebral palsy and other motor neuron diseases have equal access to AI. Researchers plan to enrich augmentative and alternate communication devices with conversational AI.

Computer screen with molecular modelling software simulating proteins.

Protein Structure Prediction

AI to study protein structures for drug design

A team of scientists is developing an AI model (SWAXSFold) to improve AlphaFold, a celebrated AI program that predicts the structure of proteins and could lead to the development of new drugs to treat diseases. AlphaFold struggles to consider how proteins change shape due to pH, temperature and other conditions. Empire AI’s computing capacity enables SWAXSFold to address this limitation by using experimental data to predict how proteins look in these environments.

Female research working on computer developing new drug.

Revolutionizing Drug Discovery

AI-Powered Polypharmacology

UB researchers in the Department of Biomedical Informatics are creating a model (CANDO) that uses AI to analyze billions of interactions between molecules. CANDO’s development will be greatly aided by Empire AI. Its primary goal is to help identify new medicines to treat diseases, however, other potential applications include new research probes, reagents, detergents, pesticides, sensors and more.

The supercomputing center of Empire AI, located at UB, will provide academic researchers in New York State with unprecedented computing power. Photo: Meredith Forrest Kulwicki.

Empire AI

UB researchers are tapping the incredible power of Empire AI.

The $400 million statewide consortium — which Gov. Kathy Hochul announced last year, including its supercomputing center located at UB, a SUNY flagship with decades of leadership in AI and data science — aims to harness AI for the betterment of society and drive innovation in New York State.

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